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Category(s): Antiparkinson's


Indications & Dosage

Benztropine is used to treat symptoms of Parkinson's disease or involuntary movements due to the side effects of certain psychiatric drugs (antipsychotics such as chlorpromazine/haloperidol). Benztropine belongs to a class of medication called anticholinergics that work by blocking a certain natural substance (acetylcholine). This helps decrease muscle stiffness, sweating, and the production of saliva, and helps improve walking ability in people with Parkinson's disease.

How to use:

Take this medication as directed by your doctor.

Do not prepare a supply in advance.

Dosage is based on your age, medical condition, and response to therapy.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

DOSAGE: 0.5-1 mg at bedtime.


Contraindicated in paediatric patients <3 yr. Do not use Benztropine: If you are allergic to Benztropine. If You have very slow or difficult breathing, or you are having an asthma attack. If you are pregnant, planning to become pregnant, or are breast-feeding. If you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement. If you have allergies to medicines, foods, or other substances. If you are allergic to other narcotic medicines (e.g., codeine, morphine, oxycodone). If you have a history of asthma, chronic obstructive pulmonary disease (COPD), or other lung or breathing problems. If you have severe drowsiness, or you have or recently have had any head injury, increased pressure in the brain, growths in the brain (e.g., tumors), or infection of the brain or nervous system. If you have a history of heart problems. Before using Benztropine: Some medical conditions may interact with Benztropine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the listed above apply to you.


Benzatropine mesilate has cumulative action, continuous supervision of patients is advisable. Concomitant use with phenothiazines, haloperidol, and/or tricyclic antidepressants, or drugs with anticholinergic or antidopaminergic actions may cause paralytic ileus, hyperthermia and heat stroken (may be fatal). Caution in patients with heart, liver, kidney or obstructive gastrointestinal (GI) diseases. Patient should observe caution while driving or performing other tasks requiring alertness because may impair mental or physical abilities. It should be used with caution in hot weather. Reduce dose or discontinue therapy if loss of appetite or weight occur.

Side Effects

Nausea, vomiting, Dry mouth, Nasal dryness, Allergic reaction, Skin rash, Paralytic ileus and Heat stroke.Convulsions, Coma, Blurred vision, Dry flushed skin, Palpitations, Pyrexia, Delirium.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. It can be interacted with solifenacin, tiotropium etc. The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also affect breathing or cause drowsiness. Therefore, tell your doctor or pharmacist if you are taking other products such as alcohol.

How It Works

Benztropine is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Benztropine partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement.


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